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目的探讨炎症因子C反应蛋白(CRP)在肺静脉源性房颤发病中的意义。方法通过建立兔肺静脉源性房颤的动物模型,并按房颤持续时间或起搏时间的不同分设亚组,应用固相酶联免疫吸附实验(ELISA)方法测定血清中CRP水平,与正常对照组比较,进行统计学分析。结果肺静脉源性房颤组中P2、P4、P6亚组与正常对照组血清CRP水平分别为(3.03±0.70)mgL、(4.93±0.81)mgL、(5.21±0.76)mgL、(1.23±0.81)mgL,均高于对照组(F=42.6719,P=0.000)。结论随着房颤持续时间的延长,血清CRP值明显升高,表明炎症状态可能参与了肺静脉源性房颤的发生、发展。
Objective To investigate the significance of inflammatory cytokine C-reactive protein (CRP) in the pathogenesis of pulmonary venous atrial fibrillation. Methods The animal models of pulmonary atrial fibrillation in rabbits were established and divided into subgroups according to the duration of atrial fibrillation or pacing duration. The levels of CRP in serum were determined by enzyme-linked immunosorbent assay (ELISA) Group comparison, statistical analysis. Results The levels of serum CRP in P2, P4 and P6 subgroups and normal control group were (3.03 ± 0.70) mgL, (4.93 ± 0.81) mgL, (5.21 ± 0.76) mgL and (1.23 ± 0.81) mgL, were higher than the control group (F = 42.6719, P = 0.000). Conclusions With the prolongation of atrial fibrillation, serum CRP levels were significantly increased, indicating that inflammation may be involved in the occurrence and development of pulmonary venous atrial fibrillation.