分析了在某医院收集到的４５株阴沟肠杆菌对１２种常用抗生素的耐药情况。院内外菌株都耐氨苄青霉素，院内菌株有６０％以上对羟苄青霉素、复方新诺明、氯霉素、头孢哌酮、头孢噻肟、头孢他啶等６种抗生素产生耐药性，而院外菌株对这些抗生素有较高的敏感性，院内菌株具有高耐药率和多重耐药的特点。目前，对阴沟肠杆菌比较敏感的药物有：丁胺卡那霉素、氟哌酸、吡哌酸。院内菌株对丁胺卡那霉素、氟哌酸和吡哌酸的耐药率分别只有７．７％、１７．９％和２５．６％。 Analysis of 45 strains of Enterobacter cloacae collected in a hospital for resistance to 12 commonly used antibiotics. Both in-vitro and in-vitro strains were resistant to ampicillin, and more than 60% of the in-hospital strains were resistant to six antibiotics, including ampicillin, cotrimoxazole, chloramphenicol, cefoperazone, cefotaxime and ceftazidime. These antibiotics have a higher sensitivity, in-hospital strains with high drug resistance and multi-drug resistance characteristics. At present, more sensitive to Enterobacter cloacae drugs are: amikacin, norfloxacin, pipemidic acid. The resistance rates of nosocomial strains to amikacin, norfloxacin and pipemidic acid were only 7.7%, 17.9% and 25.6%, respectively.