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本文报道37例成人急性粒性白血病使用强的松龙-苯丁酸氮芥酯的治疗效果。所有患者骨髓中的母细胞均在20%-90%之间(平均数67%),采用FAB协作组所制定的诊断标准,37例患者分为二组。第一组:系单用强的松龙-苯丁酸氮芥酯者,共23例,年龄均在65岁以上(平均71岁),本组患者均有下列一种或数种情况(1)贫血而需要反复输血者,(2)粒细胞减少而又合并感染,(3)血小板减少又有出血趋势者。在治疗过程中,视病情需要而加用抗菌素或输血、输血小板等。患者每日口服剂量为20-60mg,缓解率为17%,缓解期间每日服药20-40 mg。第二组:系合并使用长春新碱者,共14例年龄均在35-64岁之间(平均51岁),每日服用强的松龙一苯丁酸氮芥酯60-80 mg,以及每7-10天静注长春
This article reports the treatment of 37 patients with adult acute myeloid leukemia using prednisolone - chlorambucil. All patients had 20% -90% blast cells in the bone marrow (mean, 67%) using the diagnostic criteria developed by the FAB collaboration group and 37 patients were divided into two groups. The first group: Department of prednisolone - chlorambucil alone, a total of 23 cases, both aged 65 years of age (average 71 years), the group of patients with one or more of the following conditions (1 ) Anemia requires repeated blood transfusion, (2) neutropenia and infection, (3) thrombocytopenia and bleeding tendency. In the course of treatment, depending on the condition need to add antibiotics or blood transfusion platelets and so on. Patients daily oral dose of 20-60mg, remission rate was 17%, taking 20-40 mg daily during remission. In the second group, vincristine was used in combination. A total of 14 patients aged 35-64 years (mean 51 years) received daily 60-80 mg of prednisolone and chlorambucil, Changchun every 7-10 days intravenously