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目的探讨心脏超声对A C E I类药物福辛普利和β受体阻断药美托洛尔联合治疗慢性充血性心力衰竭临床效果评价的可行性。方法选择慢性充血性心力衰竭患者共4 2例,随机分为观察组和对照组。2组患者均经过充分休息及常规药物治疗。观察组在对照组治疗的基础上给予β受体阻滞剂美托洛尔与A C E I药物福辛普利联合治疗。疗程为8周,之后观察2组患者治疗前后心功能指标,并做统计学分析。结果与治疗前比较,观察组经过8周治疗后左室舒张末期容量指数(L V E D V I),收缩末期容量指数(L V E S V I)有明显下降,差异有统计学意义(P<0.0 1),与对照组相比,观察组的肺动脉收缩压和H R均有显著降低,差异有统计学意义(P<0.0 1),对照组内H R、P A S P均无显著变化,差异无统计学意义(P>0.0 5)。结论心脏超声作为评估卡托普利与β受体阻滞剂联合治疗心衰具有简单、无创、方法安全、方便等特点,值得临床推广应用。
Objective To investigate the feasibility of using echocardiography combined with Fosinopril, a C E class I drug, and metoprolol, a beta blocker, in the treatment of chronic congestive heart failure. Methods A total of 42 patients with chronic congestive heart failure were randomly divided into observation group and control group. The patients in both groups underwent adequate rest and routine medical treatment. The observation group was treated with metoprolol, a beta-blocker, and fosinopril, a C E I drug, on the basis of the control group. The course of treatment was 8 weeks, after which 2 groups of patients were observed before and after treatment of cardiac function, and do statistical analysis. Results Compared with before treatment, left ventricular end-diastolic volume index (LVEDVI) and end-systolic volume index (LVESVI) of the observation group decreased significantly after 8 weeks of treatment, the difference was statistically significant (P <0.01) (P <0.01). There was no significant difference in HR and PASP in the control group between the two groups (P> 0.05). Conclusions Cardiac echocardiography is a simple, noninvasive, safe and convenient method for the evaluation of captopril combined with β-blocker in the treatment of heart failure. It is worthy of clinical application.