1965年,美国芝加哥大学Rosenberg等在实验中偶然发现顺氯铵铂(Pt(NH_3)_2CI_2)有强烈抑制细胞分裂作用,他们并于1969年报导了几种铂络合物有强烈的抗癌作用。这些金属络合物与近年来所用的其他抗癌药物相比,在结构上是一种全新的化合物;且人体内含有的多种微量元素也以络合物形式存在;所以在短短的几年间,欧美各国和日本 In 1965, Rosenberg et al. of the University of Chicago accidentally discovered that cisplatinplatin (Pt(NH 3 ) 2 CI 2) strongly inhibited cell division. In 1969, they reported that several platinum complexes had strong anticancer effects. . These metal complexes are structurally new compounds compared with other anticancer drugs used in recent years; and many trace elements contained in the human body also exist as complexes; so in a few short During the year, Europe and the United States and Japan