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目的:探讨血清25-羟维生素D3[25-(OH)D3]水平与婴幼儿急性下呼吸道感染的关系及临床意义。方法:选取2011年11月至2012年5月在我院呼吸科住院的65例下呼吸道感染患儿,分为普通肺炎组35例与重症肺炎组30例,采用ELISA法测定其血清中25-(OH)D3水平,选择同期在我院儿童保健科体检的40例健康婴幼儿作为对照组。结果:(1)重症肺炎组、普通肺炎组、对照组血清25-(OH)D3水平分别为(51.92±17.65)nmol/L、(63.51±18.47)nmol/L、(79.49±18.97)nmol/L,各组间比较差异有统计学意义(P<0.01);(2)重症肺炎组患儿维生素D缺乏率为36.7%,显著高于对照组的7.5%(P<0.01)。结论:肺部感染患儿血清25-(OH)D3水平低于健康儿童,在重症肺炎患儿中更明显;重症肺炎患儿维生素D缺乏率显著高于健康儿童。因此,维生素D在呼吸道感染的发生及发展中具有重要作用。
Objective: To investigate the relationship between serum 25-hydroxyvitamin D3 [25- (OH) D3] and acute lower respiratory tract infection in infants and young children and its clinical significance. Methods: From November 2011 to May 2012, 65 children with lower respiratory tract infection who were hospitalized in the Department of Respiratory Medicine of our hospital were divided into 35 cases in common pneumonia group and 30 cases in severe pneumonia group. The serum 25- (OH) D3 levels, select the same period in our hospital child health checkup of 40 healthy infants as a control group. Results: The serum levels of 25- (OH) D3 in severe pneumonia group, common pneumonia group and control group were (51.92 ± 17.65) nmol / L, (63.51 ± 18.47) nmol / L and 79.49 ± 18.97 nmol / (P <0.01); (2) The rate of vitamin D deficiency in children with severe pneumonia was 36.7%, which was significantly higher than that in control group (7.5%, P <0.01). Conclusion: The serum 25- (OH) D3 in children with pulmonary infection is lower than that in healthy children and is more obvious in children with severe pneumonia. The incidence of vitamin D deficiency in children with severe pneumonia is significantly higher than that in healthy children. Therefore, vitamin D plays an important role in the occurrence and development of respiratory tract infections.