采用改进的液相法,以KOH为催化剂、卟啉配体和Ca(OAc)2.H2O为原料,研究了高效合成5种钙卟啉的新方法,并对KOH的催化作用机制进行了深入的探讨。经1HNMR、UV-Vis和MS表征,确认了所合成产物的结构正确,且本方法与钙卟啉的其他合成方法相比,在KOH的特殊催化作用下,可使合成反应的时间从10 h减少到0.5 h,而卟啉配体金属化时的转化率则从75%增加至99%。 A new method was developed for the efficient synthesis of five calcium porphyrins using KOH as catalyst, porphyrin ligand and Ca (OAc) 2.H2O as raw materials, and the catalytic mechanism of KOH was further studied Discussion. The structure of the synthesized product was confirmed by 1HNMR, UV-Vis and MS. Compared with the other synthesis methods of calcium porphyrin, this method can make the synthesis reaction time from 10 h To 0.5 h, whereas the conversion of porphyrin ligands increased from 75% to 99%.