全身性硬化常有原发性心肌受累,临床有明显心肌受累表现者预后不良。原发性硬皮病心肌病变的表现有胸痛、呼吸困难、心悸、充血性心衰和猝死。对硬皮病心脏的研究提示小冠状血管的功能异常可能引起心肌损伤。最近的研究证实尼卡地平能减轻全身性硬化患者 Systemic sclerosis often associated with primary myocardial involvement, clinical manifestations of myocardial involvement were poor prognosis. Primary scleroderma myocardial lesions of chest pain, dyspnea, heart palpitations, congestive heart failure and sudden death. Studies on the heart of scleroderma suggest that dysfunction of small coronary vessels may cause myocardial damage. Recent research confirms that nicardipine reduces patients with systemic sclerosis