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目的:比较地佐辛与瑞芬太尼预防硬膜外阻滞麻醉阑尾切除术牵拉反应的效果。方法选取南京市雨花医院2011—2012年收治的急性阑尾炎患者62例,按照随机数表法将患者分成观察组与对照组,各31例。在硬膜外阻滞麻醉基础上,观察组在切皮后静脉注射地佐辛,对照组在切皮后静脉注射瑞芬太尼,比较两组患者不同时间点〔T0(手术前)、T1(切皮)、T2(牵拉阑尾)、T3(手术结束)〕平均动脉压(MAP)水平、牵拉反应及不良反应发生情况。结果 T0时两组患者 MAP 水平比较,差异无统计学意义(P >0.05);T1、T2、T3时观察组患者 MAP 水平低于对照组(P <0.05)。观察组患者牵拉反应评分低于对照组(P <0.05),观察组不良反应发生率低于对照组(P <0.05)。结论地佐辛较瑞芬太尼预防硬膜外阻滞麻醉阑尾切除术牵拉反应的效果好,且安全性高。“,”Objective To compare the effect of dezocine and remifentanil in the prevention of appendectomy stretched reactions with epidural anesthesia. Methods A total of 62 cases of patients with acute appendicitis were selected from 2011 to 2012 in Nanjing Yuhua Hospital,which were randomly divided into observation group and control group,31 cases in each group. Two groups of patients were given epidural anesthesia. After skin incision,observation group was injected with dezocine, control group was injected with remifentanil,The MAP levels were compared between the two groups at the time of before opera-tion(T0 ),skin incision(T1 ),stretched appendectomy(T2 )and the end of surgery(T3 ),and the stretch reactions and ad-verse reaction were compared. Results No statistically significant difference of MAP level was found between the two groups at the time of T0 (P > 0. 05);observation group of MAP level was lower than control group at the time of T1 ,T2 ,T3 (P <0. 05). The observation group of stretched reaction score was lower than control group(P < 0. 05),and the incidence of ad-verse reactions was lower than control group(P < 0. 05). Conclusion Effect of dezocine in the prevention of appendectomy stretched reactions with epidural anesthesia is better than remifentanil,and it has a higher safety.