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目的观察放射治疗配合紫杉醇化疗对食管癌的临床疗效。方法对173例食管癌患者根据不同的治疗方法分为单纯放射治疗组(单放组)和放射治疗同步化疗组(放化疗组)。单放组80例,放疗DT 65～70Gy;放化疗组93例,放疗同时化疗,紫杉醇每周60mg。两组均随访2年。结果放化疗组的近期效果好于单放组,有显着性差异(P<0.05)。单放组1、2年生存率为51.3%(41/80)、32.5%(26/80),同步放化组为87.19%(81/93)、68.8%(64/93),两组差异有显着性(P<0.05)。结论同步放化疗优于单纯放射治疗,可明显提高食管癌的疗效。
Objective To observe the clinical effects of radiotherapy combined with paclitaxel chemotherapy on esophageal cancer. Methods 173 patients with esophageal cancer were divided into radiotherapy group (radiotherapy group) and radiotherapy and chemotherapy group (radiotherapy and chemotherapy group) according to different treatment methods. 80 patients in radiotherapy group received radiotherapy DT 65-70Gy, while 93 patients in radiotherapy and chemotherapy group received concurrent radiotherapy and 60mg paclitaxel weekly. Two groups were followed up for 2 years. Results The effect of radiotherapy and chemotherapy was better than that of radiotherapy and chemotherapy group (P <0.05). The 1-year and 2-year survival rates were 51.3% (41/80) and 32.5% (26/80) in the radiotherapy group, 87.19% (81/93) and 68.8% (64/93) in the concurrent radiotherapy group, respectively There was significant (P <0.05). Conclusions Simultaneous chemoradiotherapy is superior to radiotherapy alone and can significantly improve the efficacy of esophageal cancer.