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血小板是血液循环中最小的无核细胞成份,胞内颗粒含量丰富。在正常血循环中,血小板处于静息状态,当受到生理或病理因子刺激时,血小板发生活化,伸出伪足,释放胞内颗粒内容物,参与生理性止血或病理性血栓形成。血小板内含有颗粒主要有α-颗粒、致密体和溶酶体,其中含量最多、内容物最丰富的是α-颗粒,它含有多种与血小板功能相关的生物活性物质。随着抗人活化血小板单克隆抗体α-颗粒膜蛋白(GMP-140)单抗研制,人们对GMP-140的结构与功能有了较为深刻的了解,本文就GMP-140及其临床研究作一概述。
Platelets are the smallest non-nuclear cell components in the blood circulation, rich in intracellular particles. In normal blood circulation, platelets at rest, when stimulated by physiological or pathological factors, platelets activated, extending pseudo-foot, the release of intracellular particle content, involved in physiological bleeding or pathological thrombosis. Platelets contain particles are mainly α-particles, dense bodies and lysosomes, of which the largest content, the most abundant is the α-particles, which contains a variety of bioactive substances associated with platelet function. With the anti-human activated platelet monoclonal antibody α-granule membrane protein (GMP-140) monoclonal antibody developed, people have a more profound understanding of the structure and function of GMP-140, this article GMP-140 and its clinical research for a Overview.