冷球蛋白(Cryoglobulin)是一种遇冷沉淀的蛋白。如将患者的血清或血浆置于冰箱中数小时至数天,如见有灰黄色的沉淀,此即冷球蛋白。1933年 Wintrobe 及 Buell 在1例多发性骨髓瘤病人血清中发现有遇冷沉淀而加温后又再溶解的蛋白质。1947年 Lerner 及 Watson 将这种遇冷沉淀的蛋白质命名为冷球蛋白。血清中有冷球蛋白存在,就称为冷球蛋白血症(Cryoglobulinemia)。冷球蛋白血症于正常人罕见,但Cream(1972)报告有38％的正常人血清中有 Cryoglobulin is a cryoprecipitate protein. If the patient’s serum or plasma in the refrigerator for hours to days, such as see the gray-yellow precipitate, the cryoglobulins. In 1933 Wintrobe and Buell in a case of multiple myeloma serum found in the case of cryoprecipitate warming and then redissolved protein. In 1947, Lerner and Watson named the cryoprecipitate as cryoglobulin. Cryoglobulin exists in the serum, is called cryoglobulinemia. Cryoglobulinemia is uncommon in normal humans, but Cream (1972) reported 38% of normal human serum