黑棘皮症(AN)是一种临床上皮肤呈褐色,组织学以角化过度及乳头状瘤为特征的皮肤病损,常有不同程度色素沉着。过去认为是皮肤类癌综合征,提示胃肠道恶性肿瘤的存在。近年来发现高雄激素血症(高雄)妇女中5％～50％有 AN,并与高胰岛素血症(高胰)严重程度相关。但无选择学龄儿童中临床 AN 发生率亦达7. 1％。为了解正常及高雄妇女中 AN 发生率,验证临床检出 AN 的敏感性,分析其与胰岛索(Ins)作用及性激素水平的关系。对19例多囊卵巢综合征(PCOS)高雄妇女 Acanthosis nigricans (AN) is a clinical skin brown, histological hyperkeratosis and papilloma characterized by skin lesions, often varying degrees of pigmentation. In the past that the skin cancer syndrome, suggesting the existence of gastrointestinal cancer. In recent years, it has been found that 5% to 50% of women with hyperandrogenism (Kaohsiung) have AN and are associated with the severity of hyperinsulinemia (hyper pancreas). However, no choice of school-age children clinical AN rate of up to 7.1%. In order to understand the incidence of AN in normal and Kaohsiung women, the sensitivity of clinically detected AN was tested, and the relationship between insulin resistance and the level of sex hormones was analyzed. 19 cases of polycystic ovary syndrome (PCOS) Kaohsiung women