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用年龄、时期和出生队列对疾病的效应的定量分析方法分析肿瘤低发区苍山县胃癌死亡率在近２５ 年中的变化趋势。采用ＫＵＰＰＥＲ 数学模型，用矩阵的三角分解法求解，对三因素的各个亚层成分效应大小的定量进行了参数估计。结果表明，该县胃癌死亡率的上升趋势与１９４０ 年以后的出生队列因素有关。
Quantitative analysis of the effects of age, period, and birth cohort on disease was used to analyze the trend of gastric cancer mortality in the low-incidence region of Cangshan County in the past 25 years. Using KUPPER’s mathematical model, the trigonometric decomposition of the matrix is used to solve the problem, and the parameters of each sub-layer component effect of the three factors are quantitatively estimated. The results showed that the rising trend of gastric cancer mortality in the county was related to the birth cohort after 1940.