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目的观察透明质酸钠(HA)关节腔注射治疗老年类风湿关节炎(RA)临床疗效。方法1999-10/2003-03期间风湿科就诊的31例老年RA患者共41个对全身治疗抵抗的关节(膝36个,肩5个)接受关节腔注射HA治疗。每周1次,持续5周。记录治疗前后关节静息痛、活动痛、被动活动痛、肿胀、浮髌试验、局部皮温、步行距离痛和晨僵时间。结果完成治疗后,老年RA患者关节活动痛、静息痛、关节肿胀、浮髌试验、局部皮温、步行距离痛及晨僵时间均较治疗前明显改善(t=2.54-4.23,P<0.01)。被动活动痛评分有下降趋势(t=2.12,P=0.125)。结论全身治疗抵抗的老年RA患者部分关节腔注射HA有效。
Objective To observe the clinical efficacy of sodium hyaluronate (HA) injection in the treatment of senile rheumatoid arthritis (RA). METHODS: Thirty-one patients with rheumatoid arthritis (41 in the knee, 5 in the knee) treated with rheumatoid arthritis were enrolled in this study. Once a week for 5 weeks. Before and after treatment recorded joint resting pain, active pain, passive pain, swelling, floating patella test, local skin temperature, walking distance pain and morning stiffness time. Results After the treatment, the joint pain, rest pain, joint swelling, floating patella test, local skin temperature, walking distance pain and morning stiffness were significantly improved in elderly patients with RA (t = 2.54-4.23, P <0.01 ). The passive activity pain score had a downward trend (t = 2.12, P = 0.125). Conclusion Part of the joint cavity of elderly RA patients resistant to systemic therapy is effective in the injection of HA.