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目的:探讨HER-2/neu基因在鼻咽癌中的表达及其临床意义。方法:采用免疫组化法测定HER2/neu基因蛋白的表达。结果:69例鼻咽癌病人中52%(36/69)有HER2/neu基因蛋白表达。这种过表达与肿瘤分期、局部淋巴结和远处脏器转移以及5年总生存期、3年无病生存期均无相关性。同一病例原发病灶和复发或转移灶HER2/neu基因蛋白的表达较一致。HER2/neu基因蛋白过表达对鼻咽癌化疗的反应性不产生影响。结论:在鼻咽癌,HER2/neu基因蛋白过表达的临床意义不明,HER2/neu基因蛋白能否成为治疗新的靶点还有待进一步研究。
Objective: To investigate the expression of HER-2 / neu gene in nasopharyngeal carcinoma and its clinical significance. Methods: The expression of HER2 / neu gene protein was detected by immunohistochemistry. Results: HER2 / neu protein was expressed in 52 of 69 NPC patients (36/69). This overexpression had no correlation with tumor staging, local lymph node metastasis and distant organs, 5-year overall survival and 3-year disease-free survival. The same case of primary lesions and recurrence or metastasis of HER2 / neu gene protein expression more consistent. HER2 / neu gene protein overexpression does not affect the responsiveness of nasopharyngeal carcinoma chemotherapy. Conclusion: The clinical significance of HER2 / neu gene overexpression in NPC is unknown. Whether HER2 / neu protein can be used as a new therapeutic target remains to be further studied.