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[目的]研究血清脂联素水平与2型糖尿病肾病之间的关系及其在发生发展中的作用。[方法]选取糖尿病无肾脏改变者32人,合并早期肾病微量蛋白阳性者40例,临床肾病者32例,肾功能减退者12例以及正常对照组47例,检测研究对象血清脂联素、肾功、血脂、糖化血红蛋白、C肽、血清胰岛素、眼底等临床指标。[结果]糖尿病肾病(DN)各组血清脂联素水平与正常对照组相比差异有统计学意义。[结论]血清脂联素水平的测定对预测糖尿病肾病的发生发展有重要的作用。
[Objective] To investigate the relationship between serum adiponectin level and type 2 diabetic nephropathy and its role in the occurrence and development. [Methods] Thirty-two diabetic patients with no change of kidney, 40 patients with early stage nephropathy micro-protein positive, 32 cases with clinical nephropathy, 12 cases with renal dysfunction and 47 cases with normal control were enrolled in this study. Serum levels of adiponectin, Work, blood lipids, glycosylated hemoglobin, C-peptide, serum insulin, fundus and other clinical indicators. [Results] The levels of serum adiponectin in diabetic nephropathy (DN) group were significantly different from those in normal control group. [Conclusion] The determination of serum adiponectin plays an important role in the prediction of the occurrence and development of diabetic nephropathy.