前列腺素是从生物体内分离到的一类化合物,目前它们已在医疗和畜牧业上显示出很大的应用前途.其中前列腺素 E_1和 F_(1a)是最早分离到的二个.它们的结构较相应的前列腺素 E_2和 F_(2a)为简单,也较稳定.近年来曾报导了前列腺素 E_1和前列腺素F_(1a)的合成方法,但是其中大多数方法反而没有合成前列腺素 E_2或 F_(2a)的方法简单.本文报导了一个较简便的合成方法,希望能为前列腺素 E_1,F_(1a)及它们衍生物的应用提供一个药物来源的途径. Prostaglandins are a class of compounds isolated from living organisms, which have shown great promise in the medical and animal husbandry industries. Among them, prostaglandins E_1 and F_ (1a) are the first two isolated. Their structure Compared with the corresponding prostaglandin E_2 and F_ (2a) is simple and stable.In recent years, the synthesis of prostaglandin E_1 and prostaglandin F_1 (1a) has been reported, but most of them did not synthesize prostaglandin E_2 or F_ (2a) is a simple method.This paper reports a simple and convenient method for the synthesis of prostaglandin E_1, F_ (1a) and their derivatives and provides a source of drugs.