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目的:观察自拟加味柴胡疏肝散联合西药治疗慢性乙型肝炎的临床疗效。方法:将64例患者随机分为2组各32例。对照组口服拉米夫定、肝泰乐、齐墩果酸;治疗组在对照组治疗的基础上加服自拟加味柴胡疏肝散。观察2组治疗前后肝功能、乙肝标志物、HBV-DNA定量等指标。结果:2组治疗后各项指标均有明显改善,与治疗前比较,差异均有非常显著性意义(P<0.01),提示2组均有较好的疗效;但治疗组优于对照组,差异有显著性或非常显著性意义(P<0.05,P<0.01)。治疗后治疗组HBeAg阴转率、HBeAb阳转率和HBV-DNA阴转率明显高于对照组,2组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01),提示治疗组的疗效优于对照组。结论:自拟加味柴胡疏肝散联合西药治疗慢性乙型肝炎,能有效地改善肝功能,提高HBeAg阴转率、HBeAb阳转率和HBV-DNA阴转率。
Objective: To observe the clinical efficacy of self-made Chaihu Shugan Powder combined with Western medicine in the treatment of chronic hepatitis B. Methods: 64 patients were randomly divided into two groups of 32 cases. The control group oral lamivudine, liver Tailor, oleanolic acid; the treatment group in the control group based on the plus serving self-flavored Chaihu Shugan San. Two groups before and after treatment of liver function, hepatitis B markers, HBV-DNA quantitative indicators. Results: After treatment, the indexes of both groups were significantly improved, with significant difference compared with that before treatment (P <0.01), which indicated that both groups had better curative effect; but the treatment group was better than the control group, The difference was significant or very significant (P <0.05, P <0.01). After treatment, HBeAg negative conversion rate, HBeAb positive conversion rate and HBV-DNA negative conversion rate in the treatment group were significantly higher than those in the control group, the difference was significant or very significant (P <0.05, P <0.01), suggesting The treatment group than the control group. CONCLUSION: Self-made flavored Chaihu Shugan Powder combined with western medicine in the treatment of chronic hepatitis B can effectively improve liver function, improve HBeAg negative conversion rate, HBeAb positive conversion rate and HBV-DNA negative conversion rate.