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动脉粥样硬化(AS)是世界性的重要疾病,其发病机理十分复杂。近年报告AS病变局部、AS病人以及与AS有关疾病如心肌硬塞、脑梗塞和高脂血症等病人的血清中脂质过氧化物(LPo)增高。氧化-LDL的重要意义。提示脂质过氧化在AS发病机理中起重要作用。但是其作用机理尚有待阐明。血管内皮细胞(EC)有多种复杂的功能。EC损伤在AS发病机理中有重要的始动作用。可以设想血液中的LPo直接作用于内皮细胞,EC本身在代谢过程中也产生LPo,当促氧化一抗氧化失衡状态下,则EC极易受到脂质过氧化损伤,可能在AS发病机理中起重要作用。可是目前尚缺少实验研究的证实。现就我们的工作分为两部分报告如下。
Atherosclerosis (AS) is a worldwide major disease whose pathogenesis is very complicated. In recent years, reports of AS lesions in patients with AS, as well as AS-related diseases such as myocardial infarction, cerebral infarction and hyperlipidemia serum lipid peroxides (LPo) increased. The significance of oxidation-LDL. Tip lipid peroxidation in the pathogenesis of AS plays an important role. However, its mechanism of action remains to be elucidated. Vascular endothelial cells (ECs) have a variety of complex functions. EC damage plays an important role in the pathogenesis of AS. It is conceivable that LPO in the blood acts directly on the endothelial cells. EC itself also produces LPO during metabolism. When the pro-oxidant and anti-oxidant imbalances occur, the EC is highly susceptible to lipid peroxidation injury and may play a role in the pathogenesis of AS Important role. However, there is still a lack of experimental studies confirmed. Now on our work is divided into two parts as follows.