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牙周病是一种多因素的感染性疾病,主要表现为牙周支持组织的炎症反应和破坏,是失牙最主要的原因之一。其发病机制复杂,不只是牙周致病菌及其产物对牙齿周围组织的直接破坏作用,还与机体在免疫应答中产生的细胞因子密切联系。近年来研究表明,人细胞因子基因的表达与表观遗传修饰有关。表观遗传修饰通过调节细胞因子与牙周病相联系。
Periodontal disease is a multifactorial infectious disease, which is mainly manifested as inflammatory reaction and destruction of periodontal support tissues. It is one of the most important causes of tooth loss. The pathogenesis is complex, not only the periodontal pathogens and their products directly on the surrounding tissue damage, but also with the body in the immune response generated by cytokines are closely linked. In recent years, studies have shown that the expression of human cytokine genes and epigenetic modification. Epigenetic modifications are linked to periodontal disease by regulating cytokines.