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目的探讨血管活性物质血浆内皮素(ET)、血栓素B_2(TXB_2)、6-酮-前列腺素F_(1α)(6-keto-PGF_(1α))与再狭窄的变化规律。方法用放射免疫法测定41例冠心病患者术前及术后30 min、1d、3 d的血浆ET、TXB_2、6 keto PGF_(1α)的浓度。结果PTCA术后血浆ET水平30 min较术前显著降低(P<0.05),术后1、3 d与术前差异无统计学意义(P>0.05);术后血浆TXB_2水平30 min、1 d及3d与术前比较差异无统计学意义(P>0.05),术后血浆6-keto PGF_(1α)水平30 min较术前显著降低(P<0.05),术后1、3 d与术前比较差异无统计学意义(P>0.05)。结论PTCA术后可引起冠状动脉循环ET、TXB_2、6-keto-PGF_(1α)的波动,研究这些血管活性物质的变化规律,对PTCA急性闭塞和远期再狭窄的预防有重要的意义。
Objective To investigate the changes of plasma endothelin (ET), TXB_2, 6-keto-PGF_ (1α) and restenosis in vasoactive substances. Methods The plasma levels of ET, TXB_2, 6 keto PGF_ (1α) in 41 patients with coronary heart disease were measured by radioimmunoassay before operation and at 30 min, 1 d and 3 d after operation. Results After PTCA, plasma ET level was significantly lower than that before operation at 30 min (P <0.05), and there was no significant difference between preoperative and postoperative levels at 1 and 3 days (P> 0.05). Postoperative plasma levels of TXB_2 were 30 min and 1 d (P <0.05). The level of 6-keto PGF_ (1α) in plasma at 30 min after operation was significantly lower than that before operation (P <0.05) The difference was not statistically significant (P> 0.05). Conclusions PTCA can cause the fluctuation of ET, TXB_2, 6-keto-PGF_ (1α) in coronary circulation. Studying the variation rules of these vasoactive substances is of great significance for the prevention of PTCA acute occlusion and long-term restenosis.