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目的 :研究放疗疗程与放射性脑病潜伏期的关系 ,探讨甲强龙在放射性脑病中的治疗作用。方法 :分析 17例放射性脑病患者的临床资料 ,将患者随机分为治疗组 (甲强龙冲击疗法 )及对照组 (大剂量地塞米松 ) ,两组患者治疗后半年分别做疗效评价。结果 :10例首程放疗患者发病潜伏期为 10个月～ 6年 ,7例再程放疗的潜伏期为 2个月～ 3年 ,放疗疗程增加 ,放射性脑病的潜伏期缩短 (P <0 0 5 )。治疗组患者半年后总有效率达 85 7% ,明显高于对照组的有效率 ( 33 3 % )。结论 :放疗疗程的增加缩短了放射性脑病的潜伏期 ,再程放疗时要采用有效措施减少正常组织的剂量。甲强龙冲击疗法能有效控制放射性脑病
Objective: To study the relationship between radiotherapy course and incubation period of radiation encephalopathy and to explore the therapeutic effect of methylprednisolone on radiation encephalopathy. Methods: The clinical data of 17 patients with radiation encephalopathy were analyzed. The patients were randomly divided into treatment group (metforone impact therapy) and control group (high dose dexamethasone). The curative effect of the two groups were evaluated six months after treatment. Results: The latent period of 10 cases was 10 months to 6 years. The latency of 7 courses of reradiation was 2 months to 3 years. The course of radiotherapy was increased and the latency of radiation encephalopathy was shortened (P <0.05). After six months, the total effective rate of the treatment group reached 85.7%, which was significantly higher than that of the control group (33.3%). Conclusion: The increase of radiotherapy course shortens the incubation period of radiation encephalopathy, and the dose of normal tissue should be reduced by effective measures after reradiation. A strong shock therapy can effectively control radiation encephalopathy