乙胺碘呋酮是一广泛应用的抗心律失常药。Hewthorne等报告8例长期接受乙胺碘呋酮治疗的病人发生甲状腺功能减退,其中7例原先并无甲状腺功能障碍史或甲状腺肿,当确诊为甲状腺功能减退时,抗甲状腺抗体缺乏,而标准的过氯酸盐排出试验阳性。一例在停用乙胺碘呋酮九个月后甲状腺功能减退表现消失,过氟酸盐排出试验也恢复正常。作者认为;乙胺碘呋酮引起的甲状腺功能减 Amiodarone is a widely used antiarrhythmic drug. Hewthorne et al reported 8 cases of long-term treatment with amiodarone in patients with hypothyroidism, of which 7 had no previous history of thyroid dysfunction or goiter, when the diagnosis of hypothyroidism, anti-thyroid antibody deficiency, while the standard Perchlorate discharge test positive. In one case, the performance of hypothyroidism vanished after nine months of discontinuation of amiodarone, and the perfluorite excretion test returned to normal. The authors believe that; amiodarone-induced hypothyroidism