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过氧化物体增殖剂活化受体 (PPARs)属于核受体超家族。它在转录水平上调节脂质代谢 ,脂肪细胞分化和细胞因子的产生 ,在多代谢症候群和动脉粥样硬化中发挥作用。调脂药fibrates和抗糖尿病药gliatazones等都是其人工合成的配体。PPARs可望成为新的药物作用的靶点并为代谢紊乱性疾病的研究提供新的思路。
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. It regulates lipid metabolism, adipocyte differentiation and cytokine production at the transcriptional level, playing a role in multiple metabolic syndromes and atherosclerosis. Lipid-regulating fibrates and anti-diabetic drugs such as gliatazones are all synthetic ligands. PPARs are expected to be the targets of new drug action and provide new ideas for the study of metabolic disorders.