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目的 :观察奥沙利铂治疗晚期大肠癌临床疗效和安全性。方法 :将 10 9例晚期直肠癌病人 ,随机分为A、B、C3组 ;其中A组为奥沙利铂单药组。B组为奥沙利铂 +FU(氟尿嘧啶 ) +CF(注射用亚叶酸钙 )联合用药组 ,C组为FU +CF联合用药组。结果 :A组部分缓解 3例 ,有效率 13.6 % ;B组部分缓解 13例 ,有效率 2 7.1% ;C组部分缓解 1例 ,有效率 2 .7%。结论 :注射用奥沙利铂无论加或不加氟尿嘧啶、注射用亚叶酸钙 ,都对晚期大肠癌有一定疗效
Objective: To observe the clinical efficacy and safety of oxaliplatin in the treatment of advanced colorectal cancer. Methods: One hundred and nine patients with advanced rectal cancer were randomly divided into A, B and C3 groups. A group was oxaliplatin monotherapy group. Group B was combined with oxaliplatin + FU (fluorouracil) + CF (leucovorin for injection), and group C was FU + CF combination group. Results: A group of partial remission in 3 cases, the effective rate of 13.6%; B group of 13 cases of partial remission, the effective rate of 21.1%; C group of partial remission in 1 case, effective rate of 2.7%. Conclusion: Oxaliplatin for injection with or without fluorouracil and leucovorin for injection all have a certain effect on advanced colorectal cancer