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自70年代初期临床应用血管扩张剂治疗心力衰竭以来,有人据文献报道提出前列腺素将可能是更有意义的血管扩张剂。总之,前列腺素E_1(PGE_1)对心血管系统的作用已为公认。问题在于:几乎所有文献均提及PGE_1的致脉管炎作用,产生患者无法耐受的剧痛,使其应用受限。我们在临床实践中,也遇到同样问题,为使治疗不致因此而中断。我们将procain与PGE_1并用,确实取得了消除疼痛的明显效果,这对促使PGE_1在临床上广泛应用只是一个初步的尝试,现简要介绍给读者。
Since the early 70s of clinical application of vasodilators in the treatment of heart failure, it was reported in the literature that prostaglandins may be more meaningful vasodilators. In conclusion, the effect of prostaglandin E_1 (PGE_1) on the cardiovascular system has been well established. The problem is that almost all the literature mentions the vasculitic effect of PGE_1, producing pain that patients can not tolerate, limiting its use. We also encountered the same problems in clinical practice, so that treatment will not be interrupted. The combination of procain and PGE_1 has indeed achieved the remarkable effect of eliminating pain. This is only a preliminary attempt to make PGE_1 widely used clinically and is briefly introduced to the readers.