目的评价多次小剂量131I治疗分化型甲状腺癌伴肺转移的临床效果及不良反应。方法 24例甲状腺癌伴肺转移患者,常规口服131I 30mCi/次,必要时可重复治疗,2次间隔时间3～6个月;根据131I全身显像、血甲状腺球蛋白水平判断治疗效果;观察治疗后血常规及甲状旁腺素的变化。结果本组治疗有效率95.8%,其中治愈11例,有效12例,无效1例;131I治疗后未发生白细胞减少,无甲状旁腺素降低病例。结论采用多次小剂量131I治疗分化型甲状腺癌伴肺转移疗效好,不良反应少,可缩短患者住院时间。 Objective To evaluate the clinical effects and adverse reactions of 131I treatment of differentiated thyroid carcinoma with pulmonary metastasis by multiple small doses. Methods Twenty-four patients with thyroid carcinoma and pulmonary metastasis were treated with oral 131I 30mCi once a day for repeated treatment if necessary. The interval time ranged from 3 to 6 months. The therapeutic effect was evaluated according to 131I whole body imaging and hemoglobin level. After blood and parathyroid hormone changes. Results The effective rate of this group was 95.8%, of which 11 cases were cured, 12 cases were effective and 1 case was ineffective. No cases of leukopenia or parathyroid hormone reduction occurred after 131I treatment. Conclusions Multiple 131I treatment of differentiated thyroid cancer with lung metastasis has good curative effect and few adverse reactions, which can shorten the hospitalization time.