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目的:研究HPV(Human Papillomavirus,人类乳突病毒)感染和宫颈癌(Cervical carcinoma)及其癌前病变关系;方法:选择我院2011年1月-2012年12月收治的64例宫颈癌、CIN(Cervical Intraepithelial Neoplasias,宫颈上皮内瘤变)患者的病历资料,并和64例宫颈炎(Cervicite)患者的资料进行对比研究,对三组患者进行HPV病毒检测。结果:高危型HPV在不同类型宫颈癌中的感染率不同,其中鳞癌高危型HPV感染率最高(95.00%),宫颈癌中单一病毒感染率、双重病毒感染率、多重病毒感染率相对较高,CIN次之,III期、II期、I期病毒感染率依次降低,宫颈炎只发现单一HPV病毒感染,且单一病毒感染率远低于宫颈癌与CIN,其差异具有明显的统计学意义(p<0.05);结论:高危HPV病毒感染和宫颈癌及其癌前病变关系密切,早期高危HPV检测可以阻止高危HPV的持续性感染,降低宫颈癌的发病率。
Objective: To study the relationship between human papillomavirus (HPV) infection and cervical cancer (Cervical carcinoma) and its precancerous lesions.Methods: Sixty-four cases of cervical cancer, CIN (Cervical Intraepithelial Neoplasias, cervical intraepithelial neoplasia) patients with medical records and data and 64 cases of cervicitis (Cervicite) data were compared, the three groups of patients for HPV testing. Results: The infection rate of high-risk HPV in different types of cervical cancer was different, among which the highest infection rate of high-risk HPV was in squamous cell carcinoma (95.00%), the single virus infection rate, double virus infection rate and multi-virus infection rate in cervical cancer were relatively high , Followed by CIN, and the infection rates of stage III, stage II and stage I were successively decreased. Only single HPV infection was found in cervicitis, and the infection rate of single virus was far lower than that of cervical cancer and CIN. The difference was statistically significant ( p <0.05). CONCLUSION: High-risk HPV infection is closely related to cervical cancer and its precancerous lesions. Early detection of high-risk HPV can prevent persistent infection of high-risk HPV and reduce the incidence of cervical cancer.