以前判断甲状腺素(T_4)替代治疗是否充分,往往以原发性甲状腺功能低减临床症状的缓解及T_4、TSH值变为正常作根据。作者为了解原发性甲状腺功能低减替代治疗中临床表现与生化检查间的关系,对45例病人进行了观察。其中女性37例,男性8例,平均年龄51.5岁。其甲减诊断是根据临床表现以及T_3、T_4值减低,TSH值升高而确定的。上述病人均经3～6个月以上的治疗(用药剂量O.1～0.25mg/日)后临床上表现为甲状腺功能正常者。作 Previous judgments of thyroid hormone (T_4) replacement therapy is adequate, often with primary hypothyroidism alleviate the clinical symptoms and T_4, TSH values ​​become normal basis. In order to understand the relationship between clinical manifestations and biochemical tests in primary hypothyroidism replacement therapy, 45 patients were observed. Among them, 37 were women and 8 were males, with an average age of 51.5 years. The diagnosis of hypothyroidism is based on clinical manifestations and T_3, T_4 value decreased, TSH value increased. The above patients were treated for more than 3 to 6 months (dose O. O ~ 0.25mg / day) clinically manifested as normal thyroid function. Make