C_2b 受体(CR_1)的重要生物学功能之二就是它在清除免疫复合物方面的作用。曾有报道,循环免疫复合物携带 C_3b 并结合到红细胞膜表面的受体,然后再由这些细胞携带到肝脏,在肝脏由巨噬细胞吞噬。循环免疫复合物的这一过程显然可以通过消耗补体来加以预防。在这样的情况下,他们在局部组织沉积,产生免疫复合物介导的组织损伤。通过对某些自身免疫性疾病的观察,如系统性红斑狼疮,类风湿性关节炎等,证实在临 The second important biological function of C_2b receptor (CR_1) is its role in clearance of immune complexes. It has been reported that circulating immune complexes carry C_3b and bind to receptors on the surface of erythrocyte membranes, which are then carried to the liver and phagocytosed by macrophages in the liver. This process of circulating immune complexes can obviously be prevented by depleting the complement. In such cases, they are deposited locally and produce immune complex-mediated tissue damage. Through the observation of some autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, etc., confirmed