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蛋白C(PC)是一种由内皮细胞辅助因子活化的维生素K依赖性蛋白质,有抗凝和纤溶活性。游离蛋白S(PS:F)是PC的一种辅助因子,它能增强蛋白C的活性。为确定是否PS和PC受内皮细胞广泛损伤的影响,作者对18例成人呼吸窘迫综合征(ARDS),6例危重病人和22例正常对照者的结合和游离PS浓度、PC抗原(PC:Ag)和其机能状态进行了研究。 18例ARDS致肺急性损伤病人的年龄与6例无急性肺损伤病人无差异。肺损伤病人中,11例为败血
Protein C (PC) is a vitamin K-dependent protein that is activated by endothelial cofactors and has anticoagulant and fibrinolytic activity. Free protein S (PS: F) is a cofactor for PC that enhances protein C activity. To determine whether PS and PC were extensively damaged by endothelial cells, the authors evaluated the binding and free PS concentrations in 18 adult respiratory distress syndrome (ARDS), 6 critically ill patients and 22 normal controls, PC antigen (PC: Ag ) And its functional status were studied. There was no difference in the age of 18 ARDS patients with acute lung injury and 6 patients without acute lung injury. Of the patients with lung injury, 11 were septic