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目的:观察益生元对使用抗生素的颅脑损伤病人营养状况、肠道功能及免疫功能的影响。方法:对58例确诊为肺部感染需要使用抗生素治疗的重型颅脑损伤病人进行对照研究,其中对照组使用常规肠内营养(EN)治疗,试验组在常规EN外再添加益生元制剂20 g,3次/d。观察两组病人治疗第1、10和第20天的营养相关指标和免疫指标变化。并记录在治疗期间两组病人腹部症状及对EN的耐受情况。结果:两组病人营养相关指标及免疫指标无显著性差异(P>0.05)。但试验组病人消化道症状发生率明显低于对照组,对EN的耐受性明显优于对照组(P<0.05)。结论:益生元制剂有助于改善使用抗生素的颅脑损伤病人腹部症状以及对EN的耐受性。
Objective: To observe the effect of prebiotics on nutritional status, intestinal function and immune function in patients with brain injury using antibiotics. Methods: A total of 58 patients with severe craniocerebral injury who were diagnosed as pulmonary infection requiring antibiotics were enrolled. The control group was treated with conventional enteral nutrition (EN) , 3 times / d. The changes of nutrition related indexes and immune indexes on the 1st, 10th and 20th days of the two groups were observed. The patients’ abdominal symptoms and their tolerance to EN were recorded during treatment. Results: There was no significant difference between the two groups in nutrition-related indexes and immune indexes (P> 0.05). However, the incidence of gastrointestinal symptoms in the experimental group was significantly lower than that in the control group, and the tolerance to EN was significantly better than that of the control group (P <0.05). CONCLUSIONS: Prebiotics contribute to the improvement of abdominal symptoms and tolerance to EN in patients with craniocerebral injury using antibiotics.