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近40年来急性白血病(AL)、恶性淋巴瘤(ML)的化疗取得突破性进展。50年代儿童急性淋巴细胞性白血病(ALL)生存时间仅3个月,完全缓解率(CR)少于5%。目前,约70%儿童和30%成人ALL、40%儿童和20%成人急性非淋巴细胞性白血病(ANLL)可经化疗治愈。结合放疗,大多数儿童和青年ML可获治愈。恶性血液病治疗所以获得上述进展,一个重要原因是防治中枢神经系统(CNS)侵犯卓有成效。
Nearly 40 years of acute leukemia (AL), malignant lymphoma (ML) chemotherapy achieved a breakthrough. The 50’s childhood acute lymphoblastic leukemia (ALL) survival time of only 3 months, complete remission (CR) less than 5%. Currently, about 70% of children and 30% of adults with ALL, 40% of children and 20% of adults with acute non-lymphocytic leukemia (ANLL) are cured by chemotherapy. Combined with radiotherapy, most children and youth ML can be cured. Therefore, one of the important reasons for the above progress in the treatment of hematologic malignancies is that the prevention and treatment of the central nervous system (CNS) is very effective.