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目的 探讨细胞角蛋白 19片段 (CYFRA2 1- 1)和癌胚抗原 (CEA )在肺癌诊断方面的价值。 方法 运用电化学发光免疫分析 (ECL IA)技术测定 39例肺癌、36例肺炎和 70例健康人血清 CYFRA 2 1- 1和 CEA水平。 结果 血清 CYFRA2 1- 1和 CEA对肺癌的敏感性分别为 79.5 %和 5 3.9% ,两者联合检测敏感性 84.6 %。 结论 作为肺癌的辅助诊断指标 ,CYFRA2 1- 1优于 CEA;CYFRA 2 1- 1和 CEA联合检测 ,能提高对肺癌诊断的敏感性 ,适用于肺癌的筛查。
Objective To investigate the value of cytokeratin 19 (CYFRA21-1) and carcinoembryonic antigen (CEA) in the diagnosis of lung cancer. Methods The levels of serum CYFRA 21-1 and CEA in 39 cases of lung cancer, 36 cases of pneumonia and 70 cases of healthy people were measured by electrochemiluminescence immunoassay (ECL IA). Results The sensitivities of serum CYFRA21-1 and CEA in lung cancer were 79.5 % and 5 3.9%, respectively. The sensitivity of the combined detection of the two was 84.6 %. Conclusion As an auxiliary diagnostic marker for lung cancer, CYFRA2-1- 1 is superior to CEA; combined detection of CYFRA 21-1 and CEA can improve the sensitivity to lung cancer diagnosis and is suitable for lung cancer screening.