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目的:探讨自助式认知行为干预对广泛性焦虑症患者的疗效。方法:招募湖南省某综合性三甲医院的123例广泛性焦虑症患者，采用随机数字表法将患者随机分为对照组(n n＝62)和干预组(n n＝61)。对照组给予常规治疗，干预组在常规治疗基础上进行自助式认知行为干预。采用广泛性焦虑障碍量表(generalized anxiety disorder，GAD-7)、抑郁自评量表(self-rating depression scale，SDS)、世界卫生组织生活质量测定量表简表(WHO quality of life scale，WHOQOL-BREF)、匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index，PSQI)和服药依从性量表，对两组患者干预前(T1)、干预结束后(T2)及干预后6个月(T3)的焦虑、生活质量、睡眠质量及服药依从性进行评分并比较。采用SPSS 21.0进行数据分析，根据资料类型分别采用均数±标准差、频数和构成比进行统计描述，采用重复测量方差分析比较两组在3个时间点结局指标评价得分的组间差异、时间差异和交互效应。n 结果:干预组在干预前(T1)、干预结束后(T2)及干预后6个月(T3)焦虑得分分别为(12.74±2.02)分，(7.13±1.48)分，(6.57±1.73)分，对照组3个时间点焦虑得分为(12.08±2.11)分，(11.11±3.27)分，(10.11±3.33)分，干预组相比对照组在T2及T3时间点的焦虑程度明显缓解(n P<0.05)；此外，干预组在T2、T3时间点的生活质量及睡眠质量也明显改善(n P<0.05)；干预组在T3时间点的服药依从性明显提高(n P<0.05)。n 结论:自助式认知行为干预不仅能够显著降低广泛性焦虑症患者的焦虑程度，还能改善患者的生活质量、睡眠质量及服药依从性。“,”Objective:To investigate the effect of self-help cognitive behavioral intervention on the recovery of patients with generalized anxiety disorder.Methods:A total of 123 patients with generalized anxiety disorder were recruited from a comprehensive hospital in Hunan province. The patients were randomly assigned into control group(n n=62) and intervention group(n n=61) according to random number table. The patients in the control group were received routine treatment alone, while the patients in the intervention group were received routine treatment and WeChat-based self-help cognitive behavioral therapy. The generalized anxiety disorder(GAD-7), self-rating depression scale(SDS), WHO quality of life scale(WHOQOL-BREF), Pittsburgh sleep quality index(PSQI) and medication adherence scale(MARS) were used to measure the anxiety, depression, quality of life, sleep quality and medication compliance at three time points: before intervention (T1), after intervention (T2) and during follow-up (T3). The SPSS 21.0 was used to analyze the data.Mean±standard deviation, frequency and constituent ratio were used to describe the data based on the type of data. Repeated measure ANOVA was used to compare the between-group variation, time effect and interaction effect of two groups at 3 time points.n Results:The anxiety score of intervention group at T1, T2, T3 were (12.74± 2.02), (7.13± 1.48), (6.57±1.73) respectively, and the anxiety score of the control group were (12.08±2.11), (11.11±3.27), (10.11±3.33) respectively. Compared with the control group, the score of anxiety in the intervention group was significantly decreased at T2 and T3 (n P<0.05). Compared with control group, the sleep quality and quality of life of intervention group were significantly improved at T2, T3 (n P<0.05), and the medication compliance of the intervention group was significantly improved at T3 (n P<0.05).n Conclusion:Self-help cognitive behavioral intervention can decrease anxiety significantly and improve the quality of life, sleep quality, and medication compliance in patients with generalized anxiety disorder.