论文部分内容阅读
部分心性猝死由于缺乏明确的病理学改变,其鉴定工作一直是法医工作者的一大难题。近年来,与长QT综合征、心房颤动等致死性心律失常疾病相关基因(KCNE基因家族与KCNQ1)等研究逐渐增多。国内外研究发现KCNE和KCNQ1基因编码心肌钾离子通道,其基因异常可引起严重的心律失常,甚至导致心性猝死。因此,死后KCNE和KCNQ1的基因检测对于心性猝死鉴定具有重要意义。本文对KCNE、KCNQ1与心性猝死的相关性研究进展进行综述,希望能为法医学研究和实践提供参考。
Part of the sudden cardiac death due to the lack of a clear pathological changes, the identification of forensic workers has always been a major problem. In recent years, with the long QT syndrome, atrial fibrillation and other fatal arrhythmia disease related genes (KCNE gene family and KCNQ1) and other studies gradually increased. Domestic and foreign studies have found KCNE and KCNQ1 gene encoding myocardial potassium channel, the gene abnormalities can cause severe arrhythmia, and even lead to sudden cardiac death. Therefore, the genetic testing of KCNE and KCNQ1 after death is of great significance for the identification of sudden cardiac death. This article reviews the progress of the correlation between KCNN and KCNQ1 and sudden cardiac death, and hopes to provide a reference for forensic research and practice.