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目的探讨拉莫三嗪在丙戊酸治疗无效癫痫患者中的应用价值。方法对50例丙戊酸治疗无效的癫痫患者的临床资料进行统计分析,总结其治疗方法 ,对临床效果进行观察分析。结果拉莫三嗪单药治疗阶段和联合用药阶段本组患者治疗的总有效率分别为88.0%(44/50)、84.0%(42/50),两者之间比较差异无统计学意义(P>0.05);患者的拉莫三嗪血药浓度在联合用药阶段明显比拉莫三嗪单药治疗阶段高,差异有统计学意义(P<0.05),但拉莫三嗪单药治疗阶段中的拉莫三嗪血药浓度在再发患者和控制患者之间差异无统计学意义(P>0.05);患者的不良反应发生率达到了26.0%。结论拉莫三嗪在丙戊酸治疗无效的癫痫患者的治疗中具有高的应用价值,值得临床推广应用。
Objective To investigate the value of lamotrigine in valproic acid treatment of patients with epilepsy. Methods The clinical data of 50 patients with valproate ineffective epilepsy were analyzed statistically, and the treatment methods were summarized. The clinical effects were observed and analyzed. Results The total effective rates of the treatment of lamotrigine monotherapy and combination therapy were 88.0% (44/50) and 84.0% (42/50) respectively, with no significant difference between the two groups ( (P 0. 05). However, the lamotrigine plasma concentration in patients treated with lamotrigine alone was significantly higher than that of lamotrigine alone (P 0.05), but lamotrigine monotherapy In the lamotrigine plasma concentration between the recurrent and control patients was no significant difference (P> 0.05); the incidence of adverse reactions in patients reached 26.0%. Conclusion Lamotrigine has high value in the treatment of patients with epilepsy treated with valproic acid deficiency, which is worthy of clinical application.