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5 氟尿嘧啶 (5 ＦＵ )长循环ＰＥＧ化脂质体是一种控释、靶向制剂。它可以克服普通脂质体在生物体循环中存留时间短、易被肝脾巨噬细胞吞噬的缺点 ,延长 5 ＦＵ在血中的作用时间。本实验对 5 ＦＵ长循环脂质体在生物体内的药动学过程进行考察 ,并与 5 ＦＵ水溶液进行比较 ,
5 Fluorouracil (5 FU) Long-circulating PEGylated liposomes are a controlled-release, targeted agent. It can overcome the shortcomings of ordinary liposomes in the circulation of the organism, which is easy to be swallowed by the liver and spleen macrophages, and prolongs the action time of 5 FU in the blood. In this experiment, the pharmacokinetics of 5 FU long-circulating liposomes in vivo were investigated and compared with 5 FU aqueous solution.