世界上50%以上的人长期受到胃内病原体——幽门螺杆菌(Hp)的感染,这是大部分消化性溃疡的病因并与胃部腺癌的发生高度相关。目前对消化性溃疡的治疗方法之一是用抗生素根除Hp感染,但有相当的局限性。Hp发病机制的研究有助于鉴别细菌抗原,用以制备治疗该疾病的新的侯选疫苗。在H More than 50% of the world’s people have long been infected with the stomach’s pathogen, Helicobacter pylori (Hp), which is the cause of most peptic ulcers and is highly correlated with the development of gastric adenocarcinoma. Currently one of the treatment of peptic ulcer disease is the use of antibiotics to eradicate Hp infection, but there are considerable limitations. Studies on the pathogenesis of Hp have helped to identify bacterial antigens and to prepare new candidate vaccines for the treatment of the disease. In H