Novel isosorbide derivative containing perfluorocarbon group, bi(perfluorooctanesulfonyl)isosorbide ester as chiral dopant in liquid crystal, was synthesized. Chemical structure was characterized by elemental analysis, FT-IR, 1H NMR and 19F NMR. The optical texture of the mixture was observed by polarized optical microscopy (POM). Novel chiral dopant containing perfluorocarbon group had excellent optical activity. Its specific rotation and molar rotation were noticeable higher than those of bi(4-chloromethylbenzenecarbonic)isosorbide ester. The fluorocarbon group improved the molar rotation of chiral compound and did not affect optical rotation direction. The texture of the mixture added isosorbide derivative with fluorocarbon group showed the oily streak texture.