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目的：观察前列腺素E_1（PGE_1）及甲钴胺联合应用对糖尿病性周围神经病变的疗效。方法：将2型糖尿病合并周围神经病变的病人分为两组，A组给予PGE_1（100ug，每日一次静滴，14天一疗程），B组合用甲钴胺（500ug，隔日一次肌注，连续应用）。分别于疗程的第2、5、8周测定神经障碍的改善率并给予统计学处理。结果：①B组病人疗程末的总改善率分别为86．8％、92．5％和94．7％，明显高于A组的60．0％、77．5％和80．0％，除第5周外，均有统计学差异（P＜0．05）；②B组的显效率半数以上发生在第一疗程，并且各疗程的显效率较A组显著增高（P＜0．01）；结论：同时给予改善微循环的PGE_1和改善代谢的甲钴胺，可以显著提高显效率及总有效率，缩短疗程，增加病人对治疗的耐受性。
Objective: To observe the effect of prostaglandin E_1 (PGE_1) combined with mecobalamin on diabetic peripheral neuropathy. Methods: Patients with type 2 diabetes mellitus complicated with peripheral neuropathy were divided into two groups: group A received PGE 1 (100ug intravenously once a day for 14 days), group B received mecobalamin (500ug once every other day, Continuous application). The rates of improvement of neurological disorders were determined at the 2nd, 5th, and 8th week of the course of treatment, respectively, and the data were statistically analyzed. Results: The total improvement rate of the end of treatment in group B was 86.8%, 92.5% and 94.7%, which was significantly higher than 60.0%, 77.5% and 80.0% in group A, respectively (P <0.05). ② More than half of markedly effective rate of group B occurred in the first course of treatment, and the effective rate of each course was significantly higher than that of the A group (P <0.01). Conclusion: The simultaneous administration of PGE 1 to improve microcirculation and mecobalamin to improve metabolism can significantly improve the effective rate and total effective rate, shorten the course of treatment and increase the patients’ tolerance to treatment.