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目的:探讨脑静脉窦血栓形成（cerebral venous sinus thrombosis, CVST）颅内出血的预测因素。方法:回顾性纳入2008年1月至2021年3月期间南京大学医学院附属鼓楼医院收治的CVST患者。收集危险因素、临床表现、影像学检查及发病后90 d随访资料，对并发颅内出血组和非出血组进行比较。应用多变量n logistic回归分析确定CVST患者颅内出血的独立预测因素。n 结果:共纳入104例CVST患者，男性42例，女性62例；年龄（35.24±10.92）岁（范围22~68岁）。38例（36.84%）并发颅内出血，其中34例为出血性脑梗死，4例为同时并发蛛网膜下腔出血。单变量分析显示，颅内出血组更多见于产褥期/妊娠期患者（60.52%对48.48%；n P=0.012），更多表现为急性起病（57.89%对48.48%；n P=0.004）、局灶神经体征（47.37%对19.70%；n P=0.003）和癫痫发作（39.47%对18.18%；n P=0.017），而且血栓形成部位更多见于上矢状窦（57.89%对36.36%；n P=0.033）。多变量logistic回归分析显示，产褥期/妊娠期（优势比2.857，95%置信区间1.095~7.453；n P=0.031）和上矢状窦血栓形成（优势比2.847，95%置信区间1.110~7.302；n P=0.027）是CVST患者颅内出血的独立预测因素。发病后90 d转归分析显示，颅内出血组转归良好率与非颅内出血组差异无统计学意义（86.84%对89.39%；n P=0.695）。n 结论:产褥期和上矢状窦血栓形成是CVST患者颅内出血的独立预测因素；但颅内出血与CVST患者发病后90 d时的临床转归无关。“,”Objective:To investigate the predictors of intracranial hemorrhage in patients with cerebral venous sinus thrombosis (CVST).Methods:Patients with CVST treated in Drum Tower Hospital Affiliated to Medical School of Nanjing University from January 2008 to March 2021 were retrospectively enrolled. The risk factors, clinical manifestations, imaging examination and 90 d follow-up data were collected. The complicated intracranial hemorrhage group and non-intracranial hemorrhage group were compared. Multivariate n logistic regression analysis was used to determine the independent predictors of intracranial hemorrhage in patients with CVST.n Results:A total of 104 patients with CVST were enrolled, including 42 males and 62 females. Their age was 35.24 ± 10.92 years old (range 22-68 years). Thirty-eight patients (36.84%) were complicated with intracranial hemorrhage, including 34 hemorrhagic cerebral infarction and 4 complicated subarachnoid hemorrhage. Univariate analysis showed that compared with the non-intracerebral hemorrhage group, the intracranial hemorrhage group was more common in puerperal/pregnant patients (60.52% n vs. 48.48%; n P=0.012), with more acute onset (57.89% n vs. 48.48%; n P=0.004), focal neurological signs (47.37% n vs. 19.70%; n P=0.003) and seizure (39.47% n vs. 18.18%; n P=0.017), and the site of thrombosis was more common in the superior sagittal sinus (57.89% n vs. 36.36%; n P=0.033). Multivariate n logistic regression analysis showed that puerperium/pregnancy (odds ratio 2.857, 95% confidence interval 1.095-7.453; n P=0.031) and superior sagittal sinus thrombosis (odds ratio 2.847, 95% confidence interval 1.110-7.302; n P=0.027) were the independent predictors of intracranial hemorrhage in patients with CVST. The analysis at 90 d after onset showed that there was no significant difference in the good outcome rate between the intracranial hemorrhage group and the non-intracranial hemorrhage group (86.84% n vs. 89.39%; n P=0.695).n Conclusions:Puerperium/pregnancy and superior sagittalsinus thrombosis are the independent risk factors for intracranial hemorrhage in patients with CVST. However, complicated with intracranial hemorrhage is not associated with 90-day clinical outcomes.