目的观察地尔硫卓治疗不稳定型心绞痛的疗效及安全性。方法总结2005~2006年鞍山市第四医院40例不稳定型心绞痛,应用地尔硫卓静脉点滴,病情稳定后维持口服,监测心电图、血压、心率变化,记录病情转归及药物的不良反应。结果92%患者在用药48h,病情明显好转;2例面色潮红,未予特殊处置;1例血压偏低,补充液体量后好转。结论地尔硫卓治疗不稳定型心绞痛疗效肯定,比较安全,可供临床选择应用。 Objective To observe the efficacy and safety of diltiazem in the treatment of unstable angina pectoris. Methods Forty patients with unstable angina pectoris from the Fourth Hospital of Anshan City from 2005 to 2006 were treated with diltiazem intravenously. The patients were maintained orally after stable disease. The changes of electrocardiogram, blood pressure and heart rate were monitored. The adverse reactions were recorded. Results In 92% of the patients, the condition was obviously improved after 48 hours of treatment. Two cases of flushing had no special treatment. One case had low blood pressure and the volume of fluid was improved after the supplement. Conclusion Diltiazem is effective and safe in the treatment of unstable angina pectoris. It can be used in clinical application.