目的：观察糖尿病患者血小板活化状态和纤溶活性的变化。方法：分别采用放射免疫法、比浊法和发色底物显色法，检测２０例正常人和４０例Ⅱ型糖尿病患者（２２例无微血管病变，１８例有微血管病变）的血小板α颗粒膜蛋白（ＧＭＰ１４０）、血栓素Ｂ２（ＴＸＢ２）、６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）、血小板聚集率（ＰＡｇＲ）和血浆组织纤溶酶原激活物（ｔＰＡ）及抑制物（ＰＡＩ１）的变化。结果：糖尿病患者ＧＭＰ１４０、ＴＸＢ２、ＰＡｇＲ、ＰＡＩ１显著高于正常对照组，６ｋｅｔｏＰＧＦ１α和ｔＰＡ则明显下降，伴微血管病变者比无微血管病变者变化更明显，且ＧＭＰ１４０与ＰＡｇＲ、ＴＸＢ２呈显著正相关，而与６ｋｅｔｏＰＧＦ１α呈显著负相关。结论：血小板活化状态和纤溶活性的测定对糖尿病微血管病变的早期诊断和病情分析有重要的临床参考价值。 Objective: To observe the changes of platelet activation and fibrinolytic activity in diabetic patients. Methods: Radioimmunoassay, turbidimetry and chromogenic substrate chromogenic assay were used to detect platelet αparticles in 20 normal subjects and 40 patients with type Ⅱ diabetes mellitus (22 without microangiopathy and 18 with microangiopathy) (GMP 140), TXB2, 6-keto-PGF1α, platelet aggregation rate (PAgR) and plasma tissue plasminogen activator (tPA) Material (PAI 1) changes. Results: The GMP140, TXB2, PAgR and PAI1 of diabetic patients were significantly higher than those of the normal control group, 6ketoPGF1α and tPA were significantly decreased, with microvascular lesions than those without microvascular lesions were more obvious changes, and GMP  140 And PAgR, TXB2 was significantly positive correlation, but with 6  keto PGF1α was significantly negatively correlated. Conclusion: The determination of platelet activation status and fibrinolytic activity has important clinical value for early diagnosis and condition analysis of diabetic microangiopathy.