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最近许多回顾性研究指出:结合性和合成性雌激素与各期子宫内膜癌之间的相互关系取决于服药的剂量和持续时间。关于雌激素是真正的致癌物质还是促进癌前病变生长似有争论,根据1975年以来发表的回顾性研究指出:雌激素使用者发生宫内膜癌的危险为未使用者的4～8倍。瑞典近十年间在50～79岁的妇女中,宫内膜癌的发生率增加约20%,本文对1974至1977年间在斯德哥尔摩地区对宫内膜癌和蝶激素治疗之间的相互关系进行了逐年的对比观察。资料取材于Radiumhemmet医院收治的宫体腺癌患者622例(65例已死亡)。统计项目为诊断时年龄、绝经年龄、严次、肥胖、高血压、糖尿
Recently, many retrospective studies have pointed out that the relationship between combined and synthetic estrogen and various stages of endometrial cancer depends on the dose and duration of administration. There is controversy about whether estrogen is a true carcinogen or promoting the growth of precancerous lesions. According to a retrospective study published since 1975, estrogen users have a 4 to 8-fold greater risk of developing endometrial cancer than uninvolved individuals. In Sweden, the incidence of endometrial cancer has increased by about 20% in women aged 50 to 79 over the past 10 years. In this article, we examined the correlation between endometrial cancer and treatment with orphan hormones in Stockholm from 1974 to 1977 Year by year comparison. Data were collected from 622 cases of palace adenocarcinoma admitted to Radiumhemmet Hospital (65 deaths). Statistical items for the diagnosis of age, menopause age, severe, obesity, hypertension, diabetes