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目的 观察持续认知操作活动期间服用酪氨酸 (Tyr)的效果 ,为飞行中使用提供依据。 方法 8名健康男性青年在 2 2 :0 0～ 0 6 :0 0期间持续完成大约 8h的认知操作任务和有关量表评定 ,0 2 :0 0和 0 3:0 0接受 Tyr(或安慰剂 )试验 ,0 4:0 0和 0 5 :0 0完成脑事件相关电位 (ERPs)的测量 ,次日完成与残留效应有关的脑功能状态评定及肝、肾功能检查。 结果 Tyr明显缩短 ERPs的 P3潜伏期并减缓认知操作反应错误率的上升趋势 ,同时也减轻了嗜眠及脑疲劳症状。服用 Tyr对肝、肾功能及次日的工作影响均不显著。 结论 Tyr在对抗持续认知操作活动期间的能力下降及改善脑功能状态方面可能是一种相对无害的物质 ,存在应用于飞行员的可能性。
Objective To observe the effect of taking tyrosine (Tyr) during continuous cognitive operation to provide evidence for the use in flight. Methods Eight healthy male adolescents completed cognitive task and scale assessment at about 8 hours between 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 receiving Tyr (or comfort The test of ERPs was completed at 0:40 and 0:50, and the brain functional status and liver and kidney function tests related to residual effects were completed the next day. Results Tyr significantly shortened the P3 latency of ERPs and slowed down the error rate of cognitive operation, and also alleviated the symptoms of narcolepsy and brain fatigue. Tyr on liver, kidney function and work the next day are not significant. Conclusion Tyr may be a relatively innocuous substance in counteracting diminished abilities during cognitive activity and improving brain functional status, with the possibility of applying it to pilots.