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目的探讨硫酸镁联合乳果糖在肠镜检查肠道清洁准备中的应用。方法选取2015年2月至2016年3月在汕头市中心医院行肠镜检查的患者210例,将患者随机分为观察组(n=98)和对照组(n=112)。观察组给予硫酸镁联合乳果糖,对照组给予硫酸镁,进行术前肠道准备。肠道清洁评价采用Boston肠道准备评价量表(BBPS)进行,肠道气泡程度评价分Ⅰ~Ⅳ级(Ⅰ级为视野清晰,Ⅳ级为明显影响观察黏膜),比较两组肠道清洁有效率和肠腔气泡程度。结果观察组和对照组肠道清洁有效率分别为86.73%和70.54%,观察组肠道清洁有效率明显优于对照组(P<0.01);观察组肠腔气泡程度明显低于对照组(Z=5.947,P<0.01);观察组初次排便时间、肠内容物排清时间和排便次数分别为(50.01±6.41)min、(130.61±17.22)min和(5.10±1.73)次,均明显少于对照组[(61.21±8.11)min、(182.36±20.46)min和(7.03±2.22)次,P均<0.01];观察组和对照组不良反应总发生率分别为13.27%和16.96%,两组比较差异无统计学意义(P>0.05)。结论肠镜检查使用硫酸镁联合乳果糖进行术前肠道准备,可提高肠道清洁率、降低肠腔气泡程度,有利于内镜医师观察。
Objective To investigate the application of magnesium sulfate combined with lactulose in intestinal preparation for colonoscopy. Methods Totally 210 patients enrolled in the Shantou Central Hospital from February 2015 to March 2016 were randomly divided into observation group (n = 98) and control group (n = 112). The observation group was given magnesium sulfate combined with lactulose, and the control group was given magnesium sulfate for preoperative bowel preparation. Intestinal tract clearance was evaluated by the Boston Bowel Preparation Rating Scale (BBPS). The degree of intestinal air bubbles was classified as grade Ⅰ ~ Ⅳ (Ⅰ grade was clear vision and Ⅳ grade was obvious influence on mucosa). The intestinal clearance was compared between the two groups Efficiency and intestinal cavity bubble level. Results The effective rates of intestinal tract cleaning in the observation group and the control group were 86.73% and 70.54%, respectively. The gut clearance efficiency in the observation group was significantly better than that in the control group (P <0.01). The degree of intestinal cavity in the observation group was significantly lower than that in the control group = 5.947, P <0.01). The initial defecation time, intestinal contents clearance time and defecation times in the observation group were (50.01 ± 6.41) min, (130.61 ± 17.22) min and (5.10 ± 1.73) times respectively, (61.21 ± 8.11) min, (182.36 ± 20.46) min and (7.03 ± 2.22) times respectively in the control group (all P <0.01). The total adverse reactions in the observation group and the control group were 13.27% and 16.96% The difference was not statistically significant (P> 0.05). Conclusions Colonoscopy using magnesium sulfate combined with lactulose preoperative intestinal preparation, can improve the rate of intestinal clean, reduce the degree of airway in the intestine, is conducive to endoscopic observation.