论文部分内容阅读
目的:探讨高渗氯化钠联合纳洛酮对失血性休克患者的临床疗效及安全性。方法:收集我院收治的72例创伤失血性休克患者,随机分为实验组和对照组,每组36例,两组入院后均给予ICU常规治疗,对照组患者给予纳洛酮注射液1.2 mg加入5%葡萄糖静注,5 min/次,3次后改用4 mg持续静滴;实验组患者在对照组的基础上给予10%氯化钠液220 m L加入生理盐水80 m L配成7.5%的高渗氯化钠溶液静脉滴注。治疗结束后,对两组患者苏醒时间、血清NO、CD18水平以及临床疗效进行检测和比较。结果:与治疗前相比,两组患者的血清NO、CD18水平均下降(P<0.05);与对照组相比,实验组患者的苏醒时间较短,血清NO、CD18水平较低,并发症的发生率也较低(P>0.05)。结论:高渗氯化钠联合纳洛酮能够提高失血性休克患者的临床疗效,且安全性高,可能与其降低失血性休克患者血清NO、CD18水平有关。
Objective: To investigate the clinical efficacy and safety of hypertonic sodium chloride combined with naloxone in patients with hemorrhagic shock. Methods: Totally 72 patients with traumatic hemorrhagic shock were collected and randomly divided into experimental group and control group, with 36 cases in each group. Both groups were given ICU routine treatment after admission, while patients in control group were given naloxone injection 1.2 mg Add 5% dextrose intravenously, 5 min / time, 3 times and then use 4 mg continuous intravenous infusion; experimental group patients in the control group on the basis of 10% sodium chloride solution 220 m L added saline 80 m L dubbed 7.5% hypertonic sodium chloride solution by intravenous drip. After treatment, the recovery time, serum NO, CD18 levels and clinical efficacy of the two groups were detected and compared. Results: Compared with those before treatment, serum NO and CD18 levels decreased in both groups (P <0.05). Compared with the control group, patients in the experimental group had shorter recovery time, lower levels of serum NO and CD18, and complications The incidence was also lower (P> 0.05). Conclusion: Hypertonic sodium chloride combined with naloxone can improve the clinical curative effect in patients with hemorrhagic shock, and it is safe and may be related to the decrease of serum NO and CD18 levels in patients with hemorrhagic shock.