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本工作观察了双侧内脏神经切断大鼠在丙线800rad照后不同时间空胃运动与胃排空变化的动态规律,并结合以往内脏神经保留大鼠的实验结果进行了讨论。正常大鼠切断双侧内脏神经后空胃运动明显增强,主要表现为收缩期持续时间延长,收缩幅度增高;胃排空亦较术前加速。双侧内脏神经切断大鼠在丙线800rad照后1/24—3天空胃运动受到明显抑制,以照后1/24及3天为最著,收缩幅度降至切断神经前正常值的16.5±5.0—35.6±11.4％,切断神经后正常值的12.6±4.1—25.9±8.79％,差异非常显著(P<0.001),照后5天基本恢复正常。双侧内脏神经切断火鼠经800rad照射其胃排空的损伤和恢复规律与胃运动十分一致,照后1/24—3天胃半量排空时间(t 1/2)较正常延长约6—12倍(P<0.001),5天基本恢复正常。鉴于切断内脏神经大鼠在800rad照后其胃运动与胃排空的变化规律和内脏神经保留人鼠的结果相似,设想,交感神经在照射引起的胃运动与胃排空效应中可能不起重要作用。
In this study, we observed the dynamic changes of gastric emptying and gastric emptying at different time points after exposure to 800 rad in ciliatary nerves in rats with bilateral visceral nerve degeneration, and discussed the experimental results of rats with visceral nerve retention in the past. Normal rats cut off bilateral visceral nerves after empty stomach movement was significantly enhanced, mainly for the duration of systole prolonged contraction amplitude increased; gastric emptying also accelerated compared with preoperative. Bilateral visceral nerve transection was significantly inhibited at 1 / 24-3 days after 800 rad in C line, and the most significant lesion occurred at 1 / 24th and 3th days, and the amplitude of contraction decreased to 16.5 ± 5.0-35.6 ± 11.4%, 12.6 ± 4.1-25.9 ± 8.79% of the normal value after the nerve was cut off, the difference was very significant (P <0.001), and returned to normal after 5 days. The damage and recovery of gastric emptying induced by 800 rad irradiation of bilateral visceral nerves were consistent with that of gastric motility. The emptying time (t1 / 2) of gastric halves from 1 / 24-3 days after irradiation was about 6- 12 times (P <0.001), returned to normal after 5 days. Given that the pattern of changes in gastric motility and gastric emptying in severed visceral rats after 800 rad irradiation is similar to the results of visceral neural retention in humans, it is assumed that sympathetic nerves may not play an important role in irradiation-induced gastric motility and gastric emptying effects effect.